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Let's face it,
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Let's face it,
now that steroid-toxicity can be measured...
.png)
Let's face it,
now that steroid-toxicity can be measured...
prescribing patterns need to change
.png)
Let's face it,
now that steroid-toxicity can be measured...
prescribing patterns need to change
Clinical outcome assessments
First-in-class instruments to quantify
steroid-toxicity
Glucocorticoid Toxicity Index
Calculates change scores across nine health domains in adults
GTI Metabolic Domains
Quantifies change across four metabolic domains
Pediatric Glucocorticoid Toxicity Index
Captures the change scores in ten health domains in children
"Trial sponsors have a great opportunity and challenge to demonstrate what they mean by steroid-sparing and how that translates into healthcare benefits such as reduced hospitalizations, and improved quality of life."
Sudhakar Sridharan, MD
Vice President in Medical Science & Strategy Division at PPD/ThermoFisher
"The GTI is the first and only quantitative measure of steroid-toxicity - It allows us to quantify the scale of adverse reactions, helps us taper steroids, and look after our patients more effectively."
Wen Zhang, MD PhD
Professor Rheumatology at Peking Union Medical College Hospital (PUMCH), Beijing, China
"Steroids have a role in treating so many diseases - and yet, they do not cure any of them."
John H. Stone, MD MPH
Professor of Medicine at Harvard Medical School, and the Edward A. Fox Chair in Medicine at the Massachusetts General Hospital
"The GTI is being used in many trials around the world and the development of the GTI-MD should enable the majority of rheumatologists to quantify glucocorticoid toxicity in day-to-day practice."
Frank Buttgereit, MD
Professor of Rheumatology and Deputy Head of the Department of Rheumatology and Clinical Immunology at the Charite University Medicine (CCM) in Berlin
"Anywhere that steroids are being used in clinical studies, especially randomized controlled studies, there is a place for the GTI."
Paul Brunetta, MD
Head of Clinical & Translational Science, Sana Biotechnology
Adjunct Associate Professor, Pulmonary and Critical Care Division,
University of California, San Francisco
Find the right efficacy and safety outcome measure for your clinical trial or practice